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10.1002/mrd.22526 24 KalerL

In mitochondria, NAD + functions as an electron acceptor for NADH generated by glycolysis or the TCA cycle, thus transferring them to the respiratory chain [192]

[DOI] [PubMed] [Google Scholar] Rahman I, Smith CAD, et al

The upregulation of Sirt3 protects against impaired electron transport and ATP production, loss of mitochondrial membrane potential (MMP) and neuronal vulnerability, and treatment with Sirt3 agonists can restore mitochondrial integrity, reduce S oligomers and oxidative stress

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