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NRF2 is the primary regulator of cell survival that raises cancer progression by protecting cancer cells from ROS and DNA damage ( ROS are implicated in cancer progression, promoting cyclin D1 expression, extracellular signal-regulated kinase (ERK) and JUN N-terminal kinase (JNK) phosphorylation, and MAPK activation (Saha et al., 2017)

Always consult with a healthcare professional if you have concerns.

10.3390/metabo11120869 Metabolites

Healy, J

For a 30 mg vial: Add 1.5 mL bacteriostatic water = 20 mg/mL concentration Add 3 mL bacteriostatic water = 10 mg/mL concentration Higher concentrations mean smaller injection volumes but require more precise measurement

Mudie, Kathleen