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At higher dosages ( 125 g/mL), EGCG exhibits a cytotoxic effect, leading to the death of approximately 30% of J774A.1 cells while simultaneously inducing the production of substantial amounts of lysozyme and IL-1 , which can contribute to the reduction of inflammation [568, 581]

IOLs made from hydrophobic acrylic significantly reduce the migration of LECs onto the posterior capsule compared to older materials like polymethyl methacrylate (PMMA) or silicone (69, 7274) due to their ability to preferentially adsorb ECM proteins, notably fibronectin, from the surrounding ocular environment, which then crosslink with collagen IV in the lens capsule (75, 76)

This allows it to react with ROS in both the intra and extracellular spaces (, H 2 O 2 and hydroxyl radicals (OH ) (40)