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doi: 10.1074/jbc.M400958200

Thus, skeletal muscle ER may be a critical regulator of adiposity via indirect action as MERKO mice recapitulated the obesity phenotype observed in the whole-body ERKO mice

Its properties are also known to help the body to counteract infections

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The gut and the brain are in constant biochemical conversation through the vagus nerve, the immune system, the enteric nervous system, the bacterial metabolites that cross into circulation, and the inflammatory cytokines released when intestinal barriers fail

While mouse strains and their hybrids differ in susceptibility to hypoxia, C57BL/6 appear to be an intermediate type, neither particularly sensitive nor tolerant to hypoxia (Sheldon et al., 1998)