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Importantly, aromatase is a member of the cytochrome P450 (CYP) superfamily and induces the aromatization of androgens into estrogens

It has been found, for example, that glycation of the GPX results in a loss of enzymatic activity [103]

The third objective is to distinguish, where possible, between genetically fixed traits (local adaptation) and environmentally induced, reversible responses (phenotypic plasticity) in anthraquinone and flavonoid metabolism

Notably, SEPT9 hypermethylation, combined with high plasma levels of AFP ( 400 ng/mL), was identified as a predictor of poor OS in HCC patients receiving sorafenib or lenvatinib as first-line therapy [196]

On the other hand, the polyphenolic structure of rutin provides the ability to maintain the redox balance in fibroblasts, which has been already described elsewhere [24]

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