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Loveblad et al

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It also appears to aid in muscle recovery, and years of research have alleviated early concerns about its safety

Colchicine is not safe in patients with substantial kidney or liver disease and should not be used along with drugs such as ketoconazole (eg, Nozoral), fluconazole (Diflucan), clarithromycin (Biaxin, an antibiotic), cyclosporine (eg, Sandimmune, an immunosuppressant agent), or ritonavir (Norvir, an antiviral drug) due to the potential for drug-drug interactions

doi: 10.2174/1573399818666220418080959

This raises the prospect that MOTS-c could participate in maintaining vascular homeostasis under metabolic or oxidative challenges