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These results demonstrate another shift in the molecular regulation and output from AR after ADT failure, and suggest that specific targeting of a fraction of AR action by interfering with its interaction with its protein interactome may be valuable

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[DOI] [PubMed] [Google Scholar] 65.Jones L.L., McDonald D.A., Borum P.R

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Therefore, the mechanisms underlying autoinhibition by the XY linker may be different for each PLC enzyme, and may include electrostatic repulsion with the membrane, well ordered structural elements that occlude the active site, or both, as seems to be the case for mammalian PLC enzymes