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With regular intake, the skin gains radiance, uniformity, and vitality

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In addition to its synergistic effects with TNF, IL-17 suppresses melanogenesis through ROS-dependent autophagic melanocyte apoptosis and stimulates keratinocytes to secrete IL-1 through the nuclear factor-B (NF-B)/ROS/ NLR Family Pyrin Domain Containing 3 (NLRP3)/caspase 1 pathway 152

AMP-activated protein kinase (AMPK) is another critical tumor suppressor, acting as a cellular energy sensor activated by low ATP levels [147, 148]

Especially, in the study of osteoporosis model rats, although the mRNA expression levels of PI3K, PDK1 and Akt remained stable in bone tissues, the protein expression of their phosphorylated forms was significantly decreased, a finding that reveals key signaling changes during osteoporosis pathology (Wang et al., 2023)

BMC Biophys