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The chemical didnt gain widespread use as a malaria treatment because it was no more effective than quinine, the standard therapy at the time

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Am J Physiol Endocrinol Metab 284(4):E671E678 Joseph F, Anderson L, Goenka N, Vora J (2009) Starvation-induced true diabetic euglycemic ketoacidosis in severe depression

Leighl NB, Tsao M-S, Liu G, Tu D, Ho C, Shepherd FA, et al

The maintenance dose may be increased to 300 mg monthly for patients who tolerate the 100-mg dose and do not demonstrate a satisfactory clinical response [23]