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[39] provided evidence that miRNAs are involved in the deregulation of mitochondrial FAO by modulating the carnitine system

Mahesh et al., 2017

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The PI3K/Akt/mTOR signaling pathway is commonly involved in cell survival, growth, and proliferation in human cancers (Wang et al., 2021)

In NAFLD patients, Godex supplementation significantly reduced ALT and AST, increased mtDNA copy number, and decreased oxidative stress marker 8-oxo-7, 8-dihydro2'-deoxyguanosine (8-oxo-dG) ( L-carnitine also ameliorates oxidative stress by reducing ROS production ( Octn2, Cpt1a, Cpt2, Acadm ) while increasing metabolites associated with TCA cycle, urea cycle, and antioxidant pathways (malate, citrulline) ( Beyond mitochondrial mechanisms, L-carnitine inhibits hepatocyte autophagy and apoptosis