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On the other hands, great amounts of drug cause gastrointestinal distress that is not always well tolerated by patients

The interplay between OS and mitophagy is also reflected in their association with stress-responsive proteins such as PI3K, Akt, mTOR, AMPK, JNK, and ERK (Dewanjee et al., 2022

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Immune system aging is often characterized by hyperreactive immune responses 64 and autoimmune inflammation, where the immune system is no longer able to properly discriminate self from non-self, resulting in increased autoreactivity 65