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Statistical analyses show that the frequency of the null genotype was not significantly higher in the group of patients with nephropathy than in the group of patients without nephropathy, suggesting that the null genotype does not contribute to the development of DN in this population [59]
In eight of ten colonies tested, the introduced URA3 gene could no longer be detected (Figure S3B), and none of the negative clones grew on minimal agar without added uracil
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