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GSH-independent thioredoxin pathway), which may prevent GSH depletion-dependent oxidative stress and cell death 18

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LDHB KD significantly decreased the PPP- derived lactate but increased glycolysis-derived lactate ( Supplementary Figure 2 ), suggesting that LDHB KD reduces PPP activity, impairs NADPH synthesis and limits the conversion of cysteine to cysteine

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ADP activates GDH by binding to the NADH/ADP binding site, and thus abrogating GTP binding