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The antinociceptive effect of ALC has been confirmed in several experimental models of neuropathic pain, including streptozotocin- and chemotherapy-induced neuropathy, and the sciatic nerve chronic constriction injury model

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J Physiol 589.4 pp 963-973

Zhang R, et al

Die Einnahme sollte deshalb am Morgen erfolgen, weil Acetyl-L-Carnitin anregend wirkt, weshalb eine Einnahme am Nachmittag oder Abend nicht zu empfehlen ist, wenn die Nachtruhe gewhrleistet sein soll

In this review we focus mainly on biologically active phosphonates that originated from our institute (Institute of Organic Chemistry and Biochemistry in Prague)