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J Neuroinflammation 21:55 [DOI] [PMC free article] [PubMed] [Google Scholar] 40.Jing X, Shi H, Zhang C, Ren M, Han M, Wei X, Zhang X, Lou H (2015) Dimethyl fumarate attenuates 6-OHDA-induced neurotoxicity in SH-SY5Y cells and in animal model of Parkinsons disease by enhancing Nrf2 activity

FIGURE 2 3.2.1 TPMT polymorphisms TPMT gene is responsible for encoding thiopurine S-methyltransferase (TPMT), an enzyme that contributes to thiopurine drugs metabolism in cells

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The homocysteine-inducible, endoplasmic reticulum (ER) stress-inducible, ubiquitin-like domain member 2 (HERPUD1) in cultured HELA cells facilitate cytoprotective effects against oxidative stress by suppressing the inositol 1,4,5-triphosphate receptor and reducing the transfer of calcium ions from the endoplasmic reticulum to mitochondria [41]

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In the early 2000s, vitamin C was demonstrated to regulate the transcription factor hypoxia inducible factor-1 (HIF-1) (Hirsila et al., 2003