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Distinct patterns of multiple sclerosis pathology indicates heterogeneity on pathogenesis

Longer follow-up times allow a greater likelihood of disability progression, and future analysis should match groups based on baseline characteristics

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Furthermore, vascular endothelial injury and endothelial cell dysfunction in PCOS patients are independent of age, body weight, and metabolic abnormalities, suggesting that PCOS may be an independent risk factor for CVDs and could lead to an earlier onset of CVDs despite the presence of metabolic disorders (97, 98).The current consensus is that chronic inflammation of the vascular endothelium and the resulting endothelial dysfunction are fundamental to the pathogenesis of CVDs (99, 100)

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