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Serine catabolism generates liver NADPH and supports hepatic lipogenesis

[DOI] [PMC free article] [PubMed] [Google Scholar] 380.Sulaiman S.F., Ooi K.L

216 In addition, PKC also facilitated occludin and ZO-1 assembly via the phosphorylation of Thr residues at the C-terminus of occludin

This downregulation causes a decrease in pro-inflammatory cytokines such as IL-6, TNF-a and IL-1B

This further exacerbates ROS production and the ensuing oxidative stress [17], while also leaving the cells of the RPE with insufficient energy to divide and carry out their normal functions