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(2022) 14:e21169

Low thyroid, cortisol imbalance, or systemic inflammation can weaken tissue health

As posited by Qichun Zhang et al., the administration of BBR prior to the onset of treatment led to the activation of endogenous neuroprotective mechanisms associated with the sphingosine-1-phosphate (S1P)/HIF-1 pathway, thereby contributing to the protection of neuronal cells from the deleterious effects of hypoxia/ischemia (Zhang et al., 2016a)
While more severe forms are not all that common, some research estimates that MCAS could affect up to 17% of the population on a spectrum from very mild to debilitating symptoms.[ref] Others include very mild symptoms such as allergic rhinitis in the mast cell activation spectrum, which includes up to 30% of the population.[ref]
In many ways, they don't disable the body's own checks and balances system
For scalp hair specifically, topical delivery is probably the better-studied approach and the more targeted one
