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Conversely, GCLC overexpression led to a marked increase in GSH levels, reinforcing the role of GCLC as a key enzyme in glutathione biosynthesis and cellular defense against oxidative stress (Fig

Patients with one nonfunctional CYP2D6 null allele ( *3 , *4 , *5 , *6 , *52 , *4xn ) and one low activity CYP2D6 allele ( *9 , *10 , *29 , *41 ) were grouped as IMs, patients with one or two functional copies of the CYP2D6 gene were grouped as EMs

[DOI] [PMC free article] [PubMed] [Google Scholar] 17.Kirkland AE, Sarlo GL, Holton KF

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Yeast glutathione reductase is required for protection against oxidative stress and is a target gene for yAP-1 transcriptional regulation