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Insulin receptors in breast cancer: biological and clinical role
The observation that oxidatively modified lipoproteins in peritoneal fluid directly induce nociception in animal models, which is suppressed by vitamin E and N-acetylcysteine, provides compelling support for antioxidant therapy in pain management [41,42,43,44]
113 Besides, because of the high plasticity of the metabolic network and metabolite exchange among cancer and stromal cells, a compensatory response can be readily induced to produce limiting metabolites
In addition, MAO-generated ROS also lead to p53 activation and consequent mitochondrial oxidative damage due to the inhibition of parkin-mediated mitophagy by p53 [31]
[DOI] [PubMed] [Google Scholar] 2.Karlic H., Lohninger A
