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At baseline and at weeks 8 and 12, a clinician should assess fasting insulin and HOMA-IR (the homeostasis model assessment of insulin resistance, a calculated index derived from fasting glucose and insulin), HbA1c, high-sensitivity C-reactive protein as an inflammatory marker, and body composition by DEXA scan or bioelectrical impedance

Concomitantly, we measured increased pyruvate levels in mutant compared to control cells (Supplementary Fig
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Brunet A, Sweeney LB, Sturgill JF, Chua KF, Greer PL, Lin YX, et al