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The hypothesis has expanded to include vascular dysfunction, oxidative stress, microglial activation, and impaired proteolysis (Roda et al., 2022)

3.5 Disrupted mitochondrial dynamics Mitochondrial dynamics, which include the processes of mitochondrial fusion and fission, are essential for maintaining structural integrity, responding to metabolic demands, and eliminating damaged mitochondria (Tokuyama and Yanagi, 2023)

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People correcting a deficiency may start weekly, then taper to monthly, while wellness clients across Sacramento often choose every two to four weeks

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