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158 ER stress is another important inflammatory and pro-apoptotic factor in MASLD progression

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For observational studies reporting serum vitamin B12 levels, the certainty of evidence was upgraded from low to moderate due to the large and consistent magnitude of effect across studies, despite heterogeneity

Tissue Cell 82:102103 [DOI] [PubMed] [Google Scholar] Hassanein EHM, Mohamed WR, Hussein RM, Arafa EA (2023b) Edaravone alleviates methotrexate-induced testicular injury in rats: implications on inflammation, steroidogenesis, and Akt/p53 signaling

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It is responsible for much of the anabolic activity of growth hormone, including nitrogen retention and protein synthesis as well as muscle cell hyperplasia (increase in number of muscle cells), as well as mitogenesis (the growth of new muscle fibers)