oncogene-driven changes in the metabolism of glutathione cancer progression and treatment resistance Glutathione Restricts Serine Metabolism to

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The virus is able to persist in infected cells, allowing it to replicate and cause a chronic condition

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On the other hand, compounds that inhibit P-gp and/or multidrug resistance proteins (MRPs), including verapamil and quinidine, and the naturally occurring inhibitors flavonoids, coumarins, terpenoids, alkaloids, and saponins, among others, can promote the intracellular accumulation of methotrexate, thereby increasing the risk of toxicity [366,367]

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