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It also influences mitochondrial biogenesis by upregulating sirtuins, particularly SIRT1 and SIRT3, which play roles in deacetylating mitochondrial proteins and enhancing complex I activity [1,60]

[DOI] [PMC free article] [PubMed] [Google Scholar] 77.Gao M, Monian P, Quadri N, Ramasamy R, Jiang X

proof of principle for this utility of this approach to identify RNF12 proximal proteins was provided by identification of known substrate REX1 (Fig 1C)

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D2KO mice are more vulnerable to ventilator induced lung injury (110), whereas heterozygous D3KO mice are more vulnerable to a chemically induced worsening of restrictive cardiomyopathy, leading to congestive heart failure and increased mortality (155)