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Indeed, unlike other thiols, homocysteine incubation with endothelial cells induces an increased expression of the stress protein GRP78 and a decreased expression of glutathione peroxidase, a major intracellular antioxidant enzyme, through a mechanism that depends on an alteration of the intracellular redox potential (Kokame et al, 1996

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2024;187(2):294311.e21

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In other cases, some xenobiotics have been shown to undergo metabolic transformations that result, in part, in the formation of bis(glutathionyl) conjugates

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SELENIUM : It contributes to the normal function of the immune system by maintaining the integrity of cell membranes and preventing infection by viruses and other pathogens by participating in the formation of IL1 and T-Killer lymphocytes

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