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Studies suggest that AOD9604 does not bind the growth hormone receptor and does not activate the JAK2/STAT5 pathway, which accounts for the absence of growth-promoting or IGF-1-elevating effects observed in animal studies

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It was concluded in one study that it is not specific to a given PPI, but is a generic problem with the PPI class of drugs, because it recurs even when PPIs are interchanged.[82] It is believed that low magnesium levels resulting from PPI use is likely due to gastrointestinal malabsorption of magnesium secondary to hypochlorhydria.[222] Summary of PPIs and Nutrient Absorption As you can see, the evidence supporting the risk of critical vitamin and mineral malabsorption secondary to acid suppression by PPI use is alarming and unfortunately often overlooked by doctors and patients

When B12 levels are too low, the nerves can become damaged, leading to sensations like numbness, tingling, or a pins and needles feeling in the hands, feet, or legs

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