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We suspect that this may be an underrecognized cause for metabolic acidosis in the ICU and we would agree with the suggestion that 5-oxoproline excess should be routinely considered in the differential diagnosis for a cause for a metabolic acidosis [17].

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10.1016/s1470-2045(17)30566-1 Lancet Oncol

doi: 10.1152/ajpcell.00053.2016

Functional design of pH-responsive folate-targeted polymer-coated gold nanoparticles for drug delivery and in vivo therapy in breast cancer

Oxidative stress has been implicated in a number of diseases which include atherosclerosis, pulmonary fibrosis, cancer, Parkinson's disease, multiple sclerosis, and aging[6]