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The signaling processes responsive to glucose activation of GLUT2 include the activation of the transcription factor ChREBP

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This may be a result of aging related mitochondrial damage, hypoxia-induced ischemia or amyloid accumulation, and leads to wide-spread cellular damage through prevention of cytoprotective signaling, induction of apoptosis and neuro-inflammation (Guo et al., 2017)

A Speculative Scenario of VitB12 Deficiency Though lacking precise pathological studies, considering our current understanding of physiological pathways, it is possible to speculate on additional biochemical implications of VitB12 deficiency that may affect molecular and cellular processes (Figure 2)