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It activates pro-inflammatory responses in Kupffer cells and other liver cells, exacerbating liver injury

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However, as discussed above, CD38 is a multifunctional membrane enzyme and regulates a variety of NAD-dependent cellular processes

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Gut dysbiosis and disrupted intestinal barrier function could worsen pulmonary symptoms, augment neurological or hepatic inflammation through translocation of endotoxins and bacteria via portal veins 239,240,241

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