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Description
Aberrant astrocytes cannot provide homoeostatic support, but instead generate reactive oxygen species that may mediate neurotoxicity

So far, contradictory results have been reported
Animal studies show that increasing methionine in the diet slightly increases homocysteine levels
doi: 10.1158/1940-6207.CAPR-15-0372 75 WangS.ZhangG.ZhangP.MaX.LiF.ZhangH.et al

Schell TD, Mylin LM, Georgoff I, Teresky AK, Levine AJ, Tevethia SS

There is speculation that appropriate use of A2AR agonists could inhibit the PI3K/Akt pathway, indirectly reducing the expression of HIF-1 and pro-inflammatory cytokines while enhancing lipid metabolism