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First, free fatty acids in the cellular cytoplasm are activated by binding to Coenzyme A (CoA), forming a complex called long-chain acyl-CoA

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It remains to be shown if overexpression of the genes for these enzymes is beneficial for de novo production of L-carnitine since accumulation of intermediates in the conversion of TML to L-carnitine was not observed

Acknowledgments We would like to thank Serena Rotunno for editorial assistance in the writing of this article and Adele Manca for the design of Figure 1

Prevalence and health care costs of mitochondrial disease in Ontario, Canada: a population-based cohort study

However, the possibility that the study purely dealt with VaD is hard to consider since patients were already on donepezil, which means that a not negligible proportion might have been affected by AD or mixed dementia [55]