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A common process condition optimization method, Box-Behnken design, was used to optimize the operating variables such as temperature, pH, and enzyme quantity [34]

The cell suspension obtained from the aerial part of A

ASD is thought to result from a complex interplay of genetic and environmental factors [12]

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While both scenarios likely contribute to immune tolerance, it is generally believed that hot tumors may respond better to immune checkpoint inhibitors (ICIs) than cold tumors because the former have pre-existing cytotoxic cells potentially capable of recognizing tumor derived neoantigens.47 For cold tumors, on the other hand, antitumor immunity is likely abrogated at a much earlier stepmaking this subtype potentially more challenging to treat with ICIs

Radiographic response to neoadjuvant therapy in pleural mesothelioma should serve as a guide for patient selection for cytoreductive operations