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Due to their intrinsic characteristics, such as high energy needs to support heightened basal oxidative phosphorylation in the mitochondria, high axon terminal density, and substantial axonal arborization, dopaminergic neurons are particularly susceptible to degeneration

The exclusion criteria included: (1) current treatment for clinically significant acute or chronic diseases (cardiovascular, cerebrovascular, immune, respiratory, hepatobiliary, renal and urinary, nervous, musculoskeletal, psychiatric, infectious, blood, and neoplastic diseases)