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Atherosclerosis leads to heart attack, stroke, and senility and may lead to amputation of extremities

Characterization of thyrotropin receptor antibody-induced signaling cascades
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GABA plays a crucial role in pathways associated with ROS elimination, as evidenced by a pronounced increase in ROS levels in mutants lacking GABA shunt gene expression, underscoring the shunt's significance in ROS elimination (Al-Quraan 2015)

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