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Subgroup Analysis To explore potential sources of heterogeneity, we conducted prespecified subgroup analyses in the primary meta-analysis

MS and NMR are inherently complementary methods for metabolomics and each technique detects a distinct set of metabolites, NMR observes the most abundant metabolites while MS detects readily ionizable metabolites as low as femtomolar concentrations 37,38,39

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The adverse effects associated with both pregabalin and gabapentin that have been most commonly reported include dizziness, headache, somnolence, and edema