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Comparisons among multiple groups were performed using one-way ANOVA followed by a Bonferroni or SNK test

Sequential versus simultaneous initiation : Many clinicians prefer establishing tirzepatide tolerance and efficacy before adding other therapies, allowing clearer attribution of benefits and adverse effects

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However, these compounds may carry potential risks, including hepatic, renal, or neurotoxicity [24]

Interestingly, within the same study on lung cancer risk, the effect of the Pro/Pro genotype in conferring risk or protection differed according to smoking status, but only in those diagnosed with cancer at an older age (399)

doi:10.3748/wjg.v23.i36.6650 Mrtensson, J., Jain, A., & Meister, A