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417 In a randomized controlled trial, 100 patients with mild-to-moderate depression were treated with the SSRI sertraline plus either 300 mg per day rhodiola, 600 mg per day rhodiola, or placebo

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Rautio, J., Laine, K., Gynther, M

Two sets of sealed code break envelopes were supplied

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Therapeutic implications: modulating nodes, not just scavenging Therapy should target network nodes and compartments, not just mop up oxidants: indiscriminate antioxidant loading can blunt adaptive signalling and leave the upstream drivers untouched, whereas node-specific, compartment-aware strategies act where the chemistry originates and where signals are decoded
