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3 Results 3.1 HG stimulated inflammatory responses and altered the activities of glycolysis and OXPHOS To observe the effects of the high-glucose microenvironment on regulating the inflammatory responses in macrophages, we treated the BMDMs with HG for 24 h and found that the percentage of the M1 phenotype was increased and the proportion of the M2 phenotype was reduced, as indicated by elevated levels of CD86 and iNOS and decreased levels of CD206 and Arg-1 (Figures 1AC)

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