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Of special interest in this context are lipid peroxidation products, in particular 4-hydroxynonenal (HNE), which has been shown to both induce DNA damage [96] but also to be involved in the regulation of cell proliferation and growth as well as necrotic or apoptotic cell death by its marked ability to modulate several major pathways of cell signaling and, consequently, gene expression (for review see [97])

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For ankle injuries specifically, subcutaneous injection near the affected area at 0.25 to 0.50 mg daily for 4 to 8 weeks represents the most common protocol among researchers and biohackers

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