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It is also known that oxygen can exacerbate chromosome aberrations in lymphocytes from Fanconi Anaemia patients 53 , that the GSH precursor NAC improves genome stability in these lymphocytes 54 , and that nuclear FA increases during hematopoietic cell differentiation 42

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In another study, the authors further sustained the importance of Kla in the regulation of HR by focusing on NBS1 modification in gastric cancer cells [98]

This process is exacerbated by telomere shortening, which occurs naturally with age but can be accelerated by oxidative stress and environmental factors, leading to cellular senescence and decreased melanocyte function