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doi: 10.3389/fnut.2026.1774375 Received 23 December 2025 Revised 22 January 2026 Accepted 26 January 2026 Published 17 February 2026 Volume 13 - 2026 Edited by Abul Hossain, University of British Columbia, Canada Reviewed by Changbao Sun, Qiqihar University, China Suresh Kumar, National Institute of Biologicals, India Updates Copyright 2026 Egas-Montenegro, Echeverria-Chilla, Garca-Ulloa, Aizaga-Benalcazar and Ordoez-Araque

DOI:10.1093/bbb/zbac080 [Google Scholar] Feng YL, Cao G, Chen DQ, Vaziri ND, Chen L, Zhang J, et al

Gopal Grandhige, MD, FACS, Board-Certified Surgeon Last Reviewed: March 16, 2026 BPC-157 typically begins working within the first one to two weeks, with most patients noticing subtle improvements such as reduced soreness, better digestion, and decreased inflammation during this early phase

These Ctr1-deficient mice exhibited marked growth retardation and reduced survival rates early after birth, likely due to insufficient copper absorption and subsequent impairment of copper-dependent enzymes and proteins (18)

Those with cardiovascular concerns should watch for any changes during treatment

Shenyang City, China: China Medical University (2023)