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Developing and testing a new drug is expensive, and companies count on recouping their costs by having, in effect, a monopoly on the market for a new drug

doi: 10.1002/cncr.20727

The secondary outcomes will be the serum vitamin B12 concentration (pg/ml), adverse events (description, moment of onset and resolution, intensity, cause, steps taken), adherence to treatment (measured at each patient visit via the number of vials used for patients in the oral arm, and the number of injections given in the intramuscular arm), quality of life (measured using the EuroQoL-5D questionnaire), and patient satisfaction and preferences

Each patient will be given specific and comprehensive pre-operative instructions before their surgery

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