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Seine weite Verbreitung im Krper ermglicht es ihm , die durch freie Radikale verursachten Schden in allen Gewebearten zu neutralisieren
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Mechanistically, L2HG acts as a metabolic-epigenetic regulator that inhibits 2-oxoglutarate-dependent dioxygenases, induces histone hypermethylation, and remodels chromatin accessibility to activate an ATF3-dependent transcriptional program
Its main biological role is to act as a copper chaperoneit transports and delivers copper to cells that need it.
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