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This approach was chosen as TFE3 activity is regulated by post-translational modification rather than mRNA expression

The increase of free iron leads to Fenton reaction (Fe 2+ + H 2 O 2 Fe 3+ + OH + OH ), resulting in ROS accumulation and non-enzymatic lipid peroxidation, which leads to the imbalance of antioxidant system and membrane integrity defect, and finally leads to ferroptosis (Forcina and Dixon 2019) (Fig

NAD+ IV therapy is used to improve mental clarity, enhance energy, reduce fatigue, support addiction recovery, and promote anti-aging benefits

doi: 10.1038/ncb3575

Cardiac ageing: extrinsic and intrinsic factors in cellular renewal and senescence

A mid-day surge in cortisol levels