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Abstract Modern lifestyles have altered diet and metabolic homeostasis, with increased sugar intake, glycemic index, and prediabetes

ROS are also part of many physiological processes involved in immune response, as well as essential signaling molecules and second messengers [59]: as such, it could be argued that the reduction in the hosts scavenging capacities, rather than the increase in ROS, is the primary pathogenetic mechanism

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Raza A, Galili N, Smith S, Godwin J, Lancet J, Melchert M et al

Further, HO-1 helps sequester the highly inflammatory/destructive ferrous iron. There is increasing evidence for a central role of the Nrf2-transcription factor in controlling redox and metabolic pathways in stem cells