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The American Journal of Gastroenterology

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The elevated glycolytic flux and the decrease in pentose-phosphate flux suggest that Pink1-deficient neurons suffer a glucose metabolism reprogramming from mitochondrial oxidative to glycolytic metabolism compromising the PPP (Requejo-Aguilar et al., 2014)

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Together, these oxidative pathways underpin the transition from early-stage albuminuria to advanced renal failure

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