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One key component of the controversy relates to whether CLD is a real disease which is associated pathophysiologically to past or present B

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I didn't have pernicious anaemia, and from what I could see thee was no other kind

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This model involves the activation of innate immune cells within the brain, but T and B lymphocytes do not play a central role (Wolf, 2018), thereby distinguishing it from other MS models that involve the adaptive immune system, such as Experimental Autoimmune Encephalomyelitis (EAE), Theilers Murine Encephalopathy Virus (TMEV), and other viral models of MS (Dedoni, 2023)