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2.2 GPX2 Glutathione peroxidase 2 (GPX2) is mainly expressed in the gastrointestinal system, including the intestinal epithelium, esophageal epithelial cells, etc., and can also be detected in the human liver (Esworthy et al., 2022)

Proc Natl Acad Sci USA 2006;103:51915196

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Some have reported that serum MMA and homocysteine levels increase with age and the prevalence of elevated MMA and homocysteine levels is higher than the prevalence of low vitamin B 12 or clinically evident vitamin B 12 deficiency in the elderly.19 20 21 22 In this regard, using the assay for metabolites alone may result in overdiagnosis and overtreatment

Alteration in innate immune response by Tlr9 and the Nalp3 inflammasome in acetaminophen-induced hepatotoxicity and induction of autophagy through the removal of damaged mitochondria and oxidative stress may be the potential mechanisms for aspirin-induced cytoprotection [15], [16]

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