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Previously, it was accepted that the CNS only utilized glucose as a substrate for energy production, but within recent years, it has become evident that the CNS can metabolize lipids to produce energy 89,90

Ni 2+ -loaded chelating Sepharose was used for the affinity purification of the target protein (Figure 2B, lanes 13 right )

doi: 10.1084/jem.20070590 45 HallJACannonsJLGraingerJRDos SantosLMHandTWNaikSet al

It is also assumed that resmetirom reduces VLDL production and secretion, lowering LDL cholesterol, triglycerides, and apolipoprotein B plasma concentrations